4-amino substituted benzoquinoline.

A THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.

A thrombin inhibitor.

A thrombin inhibitor.

Inhibits ribosyldihydronicotinamide dehydrogenase.

A major lethal factor from the venom of Burmese Russell's viper, Daboia russelli siamensis.

An antineoplastic agent that inhibits BRAF kinase.

NCI: An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. (NCI Thesaurus)