When associated with conditioned and limited (not adjuvant) radiotherapy, ABVD and MOPPEBVCAD /Bleomycin, Doxorubicin, Lomustine, Mechlorethamine, Melphalan, Prednisone, Procarbazine, Vinblastine, Vincristine, Vindesine/ were superior to Stanford V chemotherapy in terms of response rate and FFS and progression-free survival. Patients were irradiated less often after MOPPEBVCAD, but this regimen was more toxic. ABVD is still the best choice when it is combined with optional, limited irradiation. When associated with conditioned and limited (not adjuvant) radiotherapy, ABVD and MOPPEBVCAD were superior to Stanford V chemotherapy in terms of response rate and FFS and progression-free survival. Patients were irradiated less often after MOPPEBVCAD, but this regimen was more toxic. ABVD is still the best choice when it is combined with optional, limited irradiation.